VERTEX PHARMACEUTICALS INCORPORATED

VRTX US92532F1003

Vertex Pharmaceuticals is a global biotechnology company that discovers and develops small-molecule drugs for the treatment of serious diseases. Its key drugs are Kalydeco, Orkambi, Symdeko, and Trikafta/Kaftrio for cystic fibrosis, where Vertex therapies remain the standard of care globally. Vertex has diversified its portfolio through Casgevy, a gene-editing therapy for beta thalassemia and sickle-cell disease. Additionally, Vertex is evaluating small-molecule inhibitors targeting acute and chronic pain using nonopioid treatments, and small-molecule inhibitors of APOL1-mediated kidney diseases. Vertex is also investigating cell therapies to deliver a potential functional cure for type 1 diabetes.

Annual Performance ¹

2021	2022	2023	2024	2025
-4%	30%	42%	-2%	0%

Annual Insiders Turnover, USD ²

¹ annual and historical performance metrics are recalculated on a daily basis;
² represents the total value of insider transactions (both buying and selling);

Insider Activity

Person	Price	Shares	Total	Published	Completed
Biller Jonathan EX VP	404.21 USD	694 Sold	280,522 USD	01/10/2025	02/10/2025
Bhatia Sangeeta N.	386.69 USD	266 Sold	102,860 USD	27/08/2025	27/08/2025
Bhatia Sangeeta N.	386.69 USD	266 Sold	102,860 USD	27/08/2025	27/08/2025
Sachs Bruce I	389.36 USD	1,634 Bought	636,214 USD	06/08/2025	06/08/2025
Kewalramani Reshma CEO	389.95 USD	5,710 Bought	2,226,615 USD	06/08/2025	06/08/2025
Sachs Bruce I	389.84 USD	3,366 Bought	1,312,201 USD	06/08/2025	06/08/2025
Kewalramani Reshma CEO	389.08 USD	4,290 Bought	1,669,153 USD	06/08/2025	06/08/2025
Altshuler David EX VP	424.69 USD	52 Sold	22,084 USD	15/05/2025	15/05/2025
Bhatia Sangeeta N.	505.86 USD	400 Sold	202,344 USD	01/05/2025	02/05/2025
Bhatia Sangeeta N.	505.86 USD	400 Sold	202,344 USD	01/05/2025	02/05/2025

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Integrated EOD Stock Data and Insider Transactions Chart

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The visibility of insider buy and sell transactions on this chart should not be the sole factor in your decision to buy or sell a particular stock. Always consider the following dynamic reports for a broader understanding of stock market activities:

• Insider Transaction Amount Distribution
• Insider Trading Seasonality
• Delta Correlation Analysis

 

Historical Performance

1M	3M	6M	1Y	3Y	5Y	All Time
-16%	-17%	-0%	19%	43%	160%	231%

Last	52W Low	52W High	All-Time Low	All-Time High	β
410.28	366.54	511.74	366.54	511.74

Company Insiders

Person / Entity	Transactions	Turnover, USD	Average, USD	First	Last
Kewalramani Reshma	10	45,385,060.70	4,538,506.07	13/11/2023	06/08/2025
Leiden Jeffrey M	9	15,207,624.66	1,689,736.07	13/12/2023	30/08/2024
Altshuler David	15	12,541,277.20	836,085.15	15/11/2023	15/05/2025
Sachs Bruce I	5	12,138,229.68	2,427,645.94	06/11/2023	06/08/2025
Arbuckle Stuart A	6	10,951,348.24	1,825,224.71	13/12/2023	15/05/2024
Bozic Carmen	8	10,655,989.32	1,331,998.67	31/10/2023	07/08/2024
Atkinson Edward Morrow Iii	8	7,999,647.44	999,955.93	12/02/2024	27/02/2025
Wagner Charles F Jr	5	6,792,517.50	1,358,503.50	20/11/2023	11/11/2024
Tatsis Ourania	12	6,316,014.92	526,334.58	12/02/2024	04/03/2025
Sachdev Amit	6	5,795,461.77	965,910.29	15/11/2023	15/05/2024
Biller Jonathan	5	3,802,310.47	760,462.09	12/02/2024	02/10/2025
Ambrose Kristen	6	2,417,094.00	402,849.00	12/02/2024	25/02/2025
Bhatia Sangeeta N.	7	1,724,031.41	246,290.20	02/05/2024	27/08/2025

Insiders marked in yellow represent long-term insiders. These are individuals who have engaged in transactions for over 3 years and have conducted at least 10 transactions or reached a cumulative turnover of $1M USD. When examining transaction clusters, we prioritize those conducted by long-term insiders for analysis.

Stock Advanced Metrics

Delta Correlation	subscribe 🔒
Upper Bound of Standardized Transaction Amount (ubsta), USD 4	subscribe 🔒

⁴ represents the maximum expected transaction amount for a company's insiders, calculated based on historical data. It provides insight into the typical range of insider transaction amounts and helps in identifying unusually large transactions.

⁵ a proprietary metric reflecting the consistency of insider trading behavior within a company. A higher discipline index suggests more regular and predictable insider transactions.