Alnylam Pharmaceuticals, Inc.

ALNY US02043Q1076

Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.

Annual Performance ¹

2021	2022	2023	2024	2025
32%	37%	-18%	21%	0%

Annual Insiders Turnover, USD ²

¹ annual and historical performance metrics are recalculated on a daily basis;
² represents the total value of insider transactions (both buying and selling);

Insider Activity

Person	Price	Shares	Total	Published	Completed
Garg Pushkal EX VP	453.51 USD	417 Sold	189,114 USD	01/10/2025	03/10/2025
Garg Pushkal EX VP	450.63 USD	810 Sold	365,010 USD	01/10/2025	03/10/2025
Garg Pushkal EX VP	451.76 USD	898 Sold	405,680 USD	01/10/2025	03/10/2025
Garg Pushkal EX VP	454.37 USD	215 Sold	97,690 USD	01/10/2025	03/10/2025
Garg Pushkal EX VP	449.99 USD	682 Sold	306,893 USD	01/10/2025	03/10/2025
Garg Pushkal EX VP	457.43 USD	147 Sold	67,242 USD	01/10/2025	02/10/2025
Greenstreet Yvonne CEO	455.82 USD	221 Sold	100,736 USD	01/10/2025	02/10/2025
Fitzgerald Kevin Joseph EX VP	446.53 USD	96 Sold	42,867 USD	01/10/2025	02/10/2025
Fitzgerald Kevin Joseph EX VP	447.92 USD	47 Sold	21,052 USD	01/10/2025	02/10/2025
Poulton Jeffrey V. EX VP	446.53 USD	150 Sold	66,980 USD	01/10/2025	02/10/2025

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Integrated EOD Stock Data and Insider Transactions Chart

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The visibility of insider buy and sell transactions on this chart should not be the sole factor in your decision to buy or sell a particular stock. Always consider the following dynamic reports for a broader understanding of stock market activities:

• Insider Transaction Amount Distribution
• Insider Trading Seasonality
• Delta Correlation Analysis

 

Historical Performance

1M	3M	6M	1Y	3Y	5Y	All Time
-21%	-2%	57%	15%	49%	182%	152%

Last	52W Low	52W High	All-Time Low	All-Time High	β
459.58	224.32	482.13	224.32	482.13

Company Insiders

Person / Entity	Transactions	Turnover, USD	Average, USD	First	Last
Greenstreet Yvonne	86	56,906,769.68	661,706.62	16/02/2024	02/10/2025
Garg Pushkal	108	26,491,807.63	245,294.52	16/02/2024	03/10/2025
Ausiello Dennis A	18	19,035,122.12	1,057,506.78	06/08/2024	14/08/2025
Bonney Michael W	16	14,036,716.94	877,294.81	27/12/2023	18/08/2025
Fitzgerald Kevin Joseph	86	10,057,032.83	116,942.24	25/06/2024	02/10/2025
Pyott David E I	4	9,385,920.00	2,346,480.00	24/06/2024	24/03/2025
Reitan Colleen F	19	8,435,475.28	443,972.38	29/08/2024	09/09/2025
Sharp Phillip A	7	7,633,820.94	1,090,545.85	29/02/2024	23/01/2025
Schulman Amy W	4	5,264,546.17	1,316,136.54	29/05/2024	25/06/2024
Poulton Jeffrey V.	75	4,609,868.81	61,464.92	16/02/2024	02/10/2025
Tanguler Tolga	66	4,043,066.86	61,258.59	16/02/2024	02/10/2025
Franchini Indrani Lall	9	345,089.22	38,343.25	02/02/2024	28/02/2024

Insiders marked in yellow represent long-term insiders. These are individuals who have engaged in transactions for over 3 years and have conducted at least 10 transactions or reached a cumulative turnover of $1M USD. When examining transaction clusters, we prioritize those conducted by long-term insiders for analysis.

Connected Companies ³

Name	ISIN	Ticker
Myriad Genetics, Inc.	US62855J1043	MYGN

³ the firms where the current insiders have executed transactions.

Stock Advanced Metrics

Delta Correlation	subscribe 🔒
Upper Bound of Standardized Transaction Amount (ubsta), USD 4	subscribe 🔒

⁴ represents the maximum expected transaction amount for a company's insiders, calculated based on historical data. It provides insight into the typical range of insider transaction amounts and helps in identifying unusually large transactions.

⁵ a proprietary metric reflecting the consistency of insider trading behavior within a company. A higher discipline index suggests more regular and predictable insider transactions.