ANNOVIS BIO, INC.

ANVS US03615A1088

Annovis Bio Inc is a clinical-stage pharmaceutical company focused on developing and commercializing drugs for the treatment of Parkinson's and Alzheimer's diseases and other neurodegenerative diseases. The pipeline products of the company consists of: Buntanetap for chronic neurodegeneration - including AD and PD; ANVS405 for acute neurodegeneration; and ANVS301 for AD.

Annual Insiders Turnover, USD ²

¹ annual and historical performance metrics are recalculated on a daily basis;
² represents the total value of insider transactions (both buying and selling);

Insider Activity

Person	Price	Shares	Total	Published	Completed
Hoffman Michael B O	2.05 USD	975,610 Bought	2,000,001 USD	28/10/2025	28/10/2025
Maccecchini Maria-luisa CEO	2.05 USD	97,561 Bought	200,000 USD	28/10/2025	28/10/2025

Integrated EOD Stock Data and Insider Transactions Chart

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The visibility of insider buy and sell transactions on this chart should not be the sole factor in your decision to buy or sell a particular stock. Always consider the following dynamic reports for a broader understanding of stock market activities:

• Insider Transaction Amount Distribution
• Insider Trading Seasonality
• Delta Correlation Analysis

 

Last	52W Low	52W High	All-Time Low	All-Time High	β
2.11	1.22	7.28	1.22	120.97

Company Insiders

Person / Entity	Transactions	Turnover, USD	Average, USD	First	Last
Hoffman Michael B	1	2,000,000.50	2,000,000.50	28/10/2025	28/10/2025
Maccecchini Maria-luisa	1	200,000.05	200,000.05	28/10/2025	28/10/2025

Insiders marked in yellow represent long-term insiders. These are individuals who have engaged in transactions for over 3 years and have conducted at least 10 transactions or reached a cumulative turnover of $1M USD. When examining transaction clusters, we prioritize those conducted by long-term insiders for analysis.

Stock Advanced Metrics

Delta Correlation	subscribe 🔒
Upper Bound of Standardized Transaction Amount (ubsta), USD 4	subscribe 🔒

⁴ represents the maximum expected transaction amount for a company's insiders, calculated based on historical data. It provides insight into the typical range of insider transaction amounts and helps in identifying unusually large transactions.

⁵ a proprietary metric reflecting the consistency of insider trading behavior within a company. A higher discipline index suggests more regular and predictable insider transactions.